Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.

Jovanović V, Abdul Aziz N, Lim YT, Ng Ai Poh A, Jin Hui Chan S, Ho Xin Pei E, Lew FC, Shui G, Jenner AM, Bowen L, McKinney EF, Lyons PA, Kemeny MD, Smith KG, Wenk MR, Macary PA. PLoS One (2013)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal...[more]

Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.

Lim WL, Lam SM, Shui G, Mondal A, Ong D, Duan X, Creegan R, Martins IJ, Sharman MJ, Taddei K, Verdile G, Wenk MR, Martins RN. Neurobiol Aging (2013)

Apolipoprotein E (ApoE) is important in facilitating the transport of lipids (cholesterol, phospholipids, and sulfatides) and plays a fundamental...[more]

Deep whole-genome sequencing of 100 southeast asian malays.

Wong LP, Ong RT, Poh WT, Liu X, Chen P, Li R, Lam KK, Pillai NE, Sim KS, Xu H, Sim NL, Teo SM, Foo JN, Tan LW, Lim Y, Koo SH, Gan LS, Cheng CY, Wee S, Yap EP, Ng PC, Lim WY, Soong R, Wenk MR, Aung T, Wong TY, Khor CC, Little P, Chia KS, Teo YY. Am J Hum Genet. (2013)

Whole-genome sequencing across multiple samples in a population provides an unprecedented opportunity for comprehensively characterizing the ...[more]

The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response.

Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P. Immunity (2012)

Recent studies suggest that the sterol metabolic network participates in the interferon (IFN) antiviral response. However, the molecular mechanisms...[more]

The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network

Thibault G, Shui G, Kim W, McAlister GC, Ismail N, Gygi SP, Wenk MR, Ng DT Mol Cell (2012)

Lipid composition can differ widely among organelles and even between leaflets of a membrane. Lipid homeostasis is critical because disequilibrium...[more]

PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner.

Summermatter S, Shui G, Maag D, Santos G, Wenk MR, Handschin C. Diabetes (2012)

Metabolic disorders are a major burden for public health systems globally. Regular exercise improves metabolic health. Pharmacological targeting of...[more]

Abc3-Mediated Efflux of an Endogenous Digoxin-like Steroidal Glycoside by Magnaporthe oryzae Is Necessary for Host Invasion during Blast Disease

Patkar RN, Xue YK, Shui G, Wenk MR, Naqvi NI. PLoS Pathog (2012)

Magnaporthe oryzae, which causes the devastating rice-blast disease, invades its host plants via a specialized infection structure called the ...[more]

Chondroitin fragments are odorants that trigger fear behavior in fish.

Mathuru AS, Kibat C, Cheong WF, Shui G, Wenk MR, Friedrich RW, Jesuthasan S. Curr Biol. 2012 Mar 20;22(6):538-44.  (2012)

The ability to detect and avoid predators is essential to survival. Various animals, from sea urchins to damselfly larvae, use injury of ...[more]

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis.

Bikman BT, Guan Y, Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA. J Biol Chem. 2012 May 18;287(21):17426-37 (2012)

Fenretinide is a synthetic retinoid that is being tested in clinical trials for the treatment of breast cancer and insulin resistance, but its...[more]

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Nat Med (2012)

Adequate lipid secretion by mammary glands during lactation is essential for the survival of mammalian offspring. However, the mechanism governing...[more]

Targeted and non-targeted analysis of membrane lipids using mass spectrometry.

Guan XL, Wenk MR Methods Cell Biol. (2012)

Mass spectrometry has gained popularity amongst cell biologists in recent years as a complementary tool to probe the metabolism and biological...[more]

Comparative lipidomic analysis of mouse and human brain with Alzheimer's disease

Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G

 J Biol Chem (2011)

Lipids are key regulators of brain function and have been increasingly implicated in neurodegenerative disorders including Alzheimer's disease ...[more]

Meibum lipid composition in asians with dry eye disease

Lam SM, Tong L, Yong SS, Li B, Chaurasia SS, Shui G, Wenk MR

 PLoS One (2011)

Background Previous lipidomic analyses of the human meibum had largely focused on individuals from non-Asian populations, despite the higher...[more]

Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis

Fei W, Li H, Shui G, Kapterian TS, Bielby C, Du X, Brown AJ, Li P, Wenk MR, Liu P, Yang H

 J Lipid Res (2011)

The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin has been implicated in adipocyte differentiation, lipid...[more]

A role for phosphatidic Acid in the formation of "supersized" lipid droplets.

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC, Yang H

 PLoS Genet

 (2011)

Lipid droplets (LDs) are important cellular organelles that govern the storage and turnover of lipids. Little is known about how the size of LDs is...[more]

Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain - Evidence of increased phospholipase A(2) activity.

Ma MT, Yeo JF, Shui G, Wenk MR, Ong WY Eur J Pain
 (2011)

Recent studies suggest that CNS phospholipase A(2) (PLA(2)) isoforms play a role in nociception, but until now, direct evidence of increased brain...[more]

Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: Applications to a rabbit model for atherosclerosis

Shui G, Cheong WF, Jappar IA, Hoi A, Xue Y, Fernandis AZ, Tan B KH, Wenk MR

 Journal of Chromatography A (2011)

Direct measurement of various sterols in crude lipid extracts in a single experiment from limited biological samples is challenging. Current mass...[more]

Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys

Shui G, Stebbins JW, Lam BD, Cheong WF, Lam SM, Gregoire F, Kusonoki J, Wenk MR

 PLoS One


 (2011)

Background Non-human primates (NHP) are now being considered as models for investigating human metabolic diseases including diabetes. Analyses of...[more]

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

Holland WL, Bikman BT, Wang LP, Yuguang G, Sargent KM, Bulchand S, Knotts TA, Shui G, Clegg DJ, Wenk MR, Pagliassotti MJ, Scherer PE, Summers SA

 Journal of Clinical Investigation

 (2011)

Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and...[more]

Lipid pathway alterations in Parkinson’s disease primary visual cortex

Cheng D, Jenner AM, Shui G, Cheong WF, Mitchell TW, Nealon JR, Kim WS, McCann H, Wenk MR, Halliday GM, Garner B

 PLoS One (2011)

BACKGROUND: We present a lipidomics analysis of human Parkinson's disease tissues. We have focused on the primary visual cortex, a region that is...[more]

The phospholipase D1 pathway modulates macroautophagy

Dall’Armi C, Hurtado-Lorenzo A, Tian H, Morel E, Nezu A, Chan RB, Yu WH, Robinson KS, Yeku O, Small SA, Frohman MA, Wenk MR, Yamamoto A and Di Paolo G

 Nature Commun
 (2011)

Although macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic...[more]

A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance.

Souza CM, Schwabe T.M.E., Pichler H, Leitner E, Guan XL, Wenk MR, Riezman I, Riezman H Metabolic Engineering  (2011)

Sterols are major lipids in eukaryotes and differ in their specific structure between species. Both cholesterol and ergosterol can form liquid...[more]

Mitochondrial changes in ageing Caenorhabditis elegans what do we learn from superoxide dismutase knockouts?

Jan Gruber, Li Fang Ng, Sheng Fong, Yee Ting Wong, Soon Ann Koh, Ce-Belle Chen, Gunghou Shui, Wei Fun Cheong, Sebastian Schaffer, Markus R. Wenk1, and Barry Halliwell PLoS (2011)

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that...[more]

Lipidomics: New Tools and Applications

Markus R. Wenk Cell (2010)

Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as bystanders in the drama of biological systems. The emerging field...[more]

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

Yang PY, Liu K, Ngai MH, Lear MJ, Wenk MR, Yao SQ  Journal of the American Chemical Society (2010)

Orlistat, or tetrahydrolipstatin (THL), is an FDA-approved antiobesity drug with potential antitumor activities. Cellular off-targets and potential...[more]

Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism

Barry P. Young, John J. H. Shin, Rick Orij, Jesse T. Chao, Shu C. Li,Xue Li Guan, Anthony Khong, Eric Jan, Markus R. Wenk, Will A. Prinz, Gertien J. Smits & Christopher J. R. Loewen Science (2010)

Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such...[more]

Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis BCG

Low Kai Leng; Shui Guanghou; Klaus Natter; Wee Kiang Yeo; Sepp D. Kohlwein; Thomas Dick; Markus R Wenk JBC (2010)

Mycobacteria store triacylglycerols (TGs) in the form of intracellular lipid droplets (LDs) during hypoxia-induced nonreplicating persistence. These...[more]

Mitochondrial cardiolipin involved in outer membrane protein biogenesis: implications for Barth syndrome

Natalia  Gebert, 1,2,3,8   Amit  S.  Joshi, 4,8   Stephan  Kutik, 1,2,8,9   Thomas  Becker, 1   Matthew  McKenzie, 5  Xue Li Guan, 6  Ved P. Mooga, 5  David A. Stroud, 1,3  Markus R. Wenk, 6  Peter  Rehling, 7   Chris  Meisinger, 1,2   Michael  T.  Ryan, Current Biology (2010)

The biogenesis of mitochondria requires the import of a large number of proteins from the cytosol [1,2]. Although numerous studies have...[more]

A small molecule fusion inhibitor of dengue virus

Poh, M. K.,Yip, A.,Zhang, S.,Priestle, J. P.,Ma, N. L.,Smit, J. M.,Wilschut, J.,Shi, P. Y.,Wenk, M. R.,Schul, W. Antiviral Res (2010)

The dengue virus envelope protein plays an essential role in viral entry by mediating fusion between the viral and host membranes. The crystal...[more]

Structural and biological diversity of lipopolysaccharides from Burkholderia pseudomallei and Burkholderia thailandensis

Novem V, Shui G, Wang D, Bendt AK, Sim SH, Liu Y, Thong TW, Sivalingam SP, Ooi EE, Wenk MR and Tan G  J Clin Vaccine Immunol, 16(10), 1420-1428. (2009)

Burkholderia pseudomallei, the etiological agent of melioidosis, is a facultative intracellular pathogen. As a Gram-negative bacterium, the outer...[more]

XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis

McGehee AM, Dougan SK, Klemn EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL and H CCA. J Immunol 183(6), 3690-3699. (2009)

The accumulation of misfolded secreted IgM in the endoplasmic reticulum (ER) of XBP-1-deficient B cells has been held responsible for the inability...[more]

Triacylglycerol utilization is required for the re-growth of in vitro hypoxic non-replicating mycobacterium Bovis Bacillus Calmette-Guerin

Low KL, Rao PSS, Shui G, Bendth AK, Pethe K, Dick T and Wenk MR J Bacteriol 191(16), 5037-5043. (2009)

Mycobacteria store triacylglycerols (TGs) under various stress conditions such as hypoxia, exposure to nitric oxide and acidic environments. These...[more]

Lipid-based biomarkers for cancer

Fernandis AZ and Wenk MR Journal of Chromatography B 877(26), 2830-2835. (2009)

Lipids play important and diverse roles in cells. Most obvious functions are storage of chemical energy, provision of structural support of...[more]

Evidence that selective changes in the lipid composition of raft-membranes occur during respiratory syncytial virus infection.

Yeo DSY, Chan R, Brown G, Ying L, Rutejo R, Aitken J, Tan BH, Wenk MR and Sugrue RJ  Virology 386(1), 168-82. (2009)

We examined the structure of lipid-raft membranes in respiratory syncytial virus infected cells. Cholesterol depletion studies using...[more]

Identification and characterization of the lipid binding property of GrlR, a locus of enterocyte effacement regulator.

Jobichen C, Fernandis AZ, Leung KY, Mok HYK, Wenk MR and Sivaraman J  Biochemical Journal 420(2),191-199.  (2009)

Lipocalins are a broad family of proteins identified initially in eukaryotes and more recently in gram-negative bacteria. The functions of lipocalin...[more]

The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.

Kutik S, Rissler M, Guan XL, Guiard B, Shui G, Gebert N, Heacock PN, Rehling P, Dowhan W, Wenk MR, Pfanner N, Wiedemann N Journal of Cell Biology 183(7), 1213-1221. (2008)

The mitochondrial inner membrane contains different translocator systems for the import of presequence-carrying proteins and carrier proteins. The...[more]

Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides.

Chan R, Uchil PD, Jin J, Shui G, Ott DE, Mothes W, Wenk MR  Journal of Virology 82(22), 11228-11238 (2008)

Retroviruses acquire a lipid envelope during budding from the membrane of their hosts. Therefore, the composition of this envelope can provide...[more]

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome.

Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G Proceedings of the National Academy of Science of the U.S.A. 105(27), 9415-9420 (2008)

Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses,...[more]

Biochemistry of inositol lipids.

Guan X, Wenk MR Frontiers in Bioscience 13, 3239-3251 (2008)

Nature has created an immense combinatorial and structural heterogeneity among lipids. It is becoming increasingly accepted that the vast range of...[more]

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.

Fei W, Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H Journal of Cell Biology 180(3),473-482 (2008)

Lipid droplets (LDs) are emerging cellular organelles that are of crucial importance in cell biology and human diseases. In this study, we present...[more]

Sensitive profiling of chemically diverse bioactive lipids.

Shui G, Bendt AK, Pethe K, Dick T, Wenk MR Journal of Lipid Research 48(9), 1976-1984 (2007)

Here, we present an improved method for sensitive profiling of lipids in a single high-performance liquid chromatography-electrospray...[more]

The identification of antioxidants in dark soy sauce.

Wang H, Jenner AM, Lee CY, Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B Free Radical Research 41(4), 479-488. (2007)

Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo....[more]

Lipidomics in drug and biomarker development

Wenk MR Expert Opinion on Drug Discovery 1(7), 723-736  (2006)

Lipidomics is an emerging field in biomedical research. It aims at systems scale detection, characterisation and quantification of lipids. Lipidomics...[more]

Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons

Koh CHV, Whiteman ML, Lib QX, Halliwell B, Jenner AM, Wong BS, Laughton KM, Wenk MR, Masters CL, Beart PM, Bernarde O, and Cheung NS  Journal of Neurochemistry 98(4), 1278-1289 (2006)

Findings that antioxidant treatment may be beneficial in Alzheimer's disease indicate that oxidative stress is an important factor in its...[more]

Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.

Huang Q, Shen HM, Shui G, Wenk MR, Ong CN
 Cancer Research 66(11),5807-5815. (2006)

Cell adhesion and spreading is a crucial step in the metastatic cascade of cancer cells, and interruption of this step is considered to be a logical...[more]

Peculiarities of host cholesterol transport to the unique intracellular vacuole containing Toxoplasma.

Sehgal A, Bettiol S, Pypaert M, Wenk MR, Kaasch A, Blader IJ, Joiner KA, Coppens I Traffic 6(12), 1125-1141. (2005)

The intracellular protozoan Toxoplasma gondii is auxotrophic for low-density lipoprotein (LDL)-derived cholesterol (C). We previously showed that T....[more]

The emerging field of lipidomics

Wenk MR Nature Reviews Drug Discovery 4(7), 594-610  (2005)

The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large number of genetic studies and by many human diseases that...[more]

InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1.

Johenning FW, Wenk MR, Uhlén P, Degray B, Lee E, De Camilli P, Ehrlich BE Biochemical Journal 382(2), 687-694.  (2004)

Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] plays an important physiological role as a precursor for the InsP3-mediated intracellular...[more]

Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.

Wenk MR, De Camilli P Proceedings of the National Academy of Science of the U.S.A. 101(22), 8262-8269  (2004)

Great progress has been made in the elucidation of the function of proteins in membrane traffic. Less is known about the regulatory role of lipids in...[more]

Assembly of endocytosis-associated proteins on liposomes.

Wenk MR and De Camilli P  Methods in Enzymology 372, 248-260. (2003)

ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.

Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V  Journal of Cell Biology 162(1),113-124.  (2003)

Clathrin-mediated endocytosis of synaptic vesicle membranes involves the recruitment of clathrin and AP-2 adaptor complexes to the presynaptic plasma...[more]

Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.

Guo J, Wenk MR, Pellegrini L, Onofri F, Benfenati F, De Camilli P Proceedings of the National Academy of Science of the U.S.A. 100(7), 3995-4000 (2003)

Phosphorylation of inositol phospholipids plays a key role in cellular regulation via the generation of intracellular second messengers. In addition,...[more]

Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle.

Lee E, Marcucci M, Daniell L, Pypaert M, Weisz OA, Ochoa GC, Farsad K, Wenk MR, De Camilli P Science 297(5584), 1193-1196 (2002)

In striated muscle, the plasma membrane forms tubular invaginations (transverse tubules or T-tubules) that function in depolarization-contraction...[more]

Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nat Struct Biol 8, 1031-1036.

Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, and Strynadka NC Nature Structural Biology 8(12), 1031-1036 (2001)

Several Gram-negative bacterial pathogens have evolved a type III secretion system to deliver virulence effector proteins directly into eukaryotic...[more]

PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.

Wenk MR, Pellegrini L, Klenchin VA, Di Paolo G, Chang S, Daniell L, Arioka M, Martin TF, and De Camilli P  Neuron 32(1), 79-88 (2001)

Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and...[more]

A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation.

Marcus SL, Wenk MR, Steele-Mortimer O, Finlay BB FEBS Letters 494(3), 201-207. (2001)

The Ser-Thr kinase Akt is activated in epithelial cells by Salmonella enterica serovar typhimurium. The bacterial effector SigD, which is...[more]

Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity.

Nemoto Y, Kearns BG, Wenk MR, Chen H, Mori K, Alb JG Jr, De Camilli P, Bankaitis VA Journal of Biological Chemistry 275(44), 34293-34305 (2000)

The Saccharomyces cerevisiae SAC1 gene was identified via independent analyses of mutations that modulate yeast actin function and alleviate the...[more]

Essential role of phosphoinositide metabolism in synaptic vesicle recycling.

Cremona O, Di Paolo G, Wenk MR, Luthi A, Kim WT, Takei K, Daniell L, Nemoto Y, Shears SB, Flavell RA, McCormick DA and De Camilli P Cell 99(2), 179-188 (1999)

Growing evidence suggests that phosphoinositides play an important role in membrane traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was...[more]

Magainin 2 amide interaction with lipid membranes: calorimetric detection of peptide binding and pore formation.

Wenk MR and Seelig J Biochemistry 37(11), 3909-3916. (1998)

The interaction of the antibiotic magainin 2 amide (M2a) with lipid bilayers was investigated with high-sensitivity titration calorimetry. The...[more]

Vesicle-micelle transformation of phosphatidylcholine/octyl-beta-D-glucopyranoside mixtures as detected with titration calorimetry.

Wenk MR and Seelig J Journal of Physical Chemistry B 101(26), 5224-5231 (1997)

The vesicle−micelle transition of lipid bilayers induced by the addition of the nonionic detergent octyl-β-d-glucopyranoside (OG) was studied with...[more]

Paclitaxel partitioning into lipid bilayers.

Wenk MR, Fahr A, Reszka R and Seelig J Journal of Pharmaceutical Sciences 85(2), 228-231 (1996)

Paclitaxel (taxol) is diterpenoid anticancer drug with a new mechanism of cytostatic action. It is under investigation in clinical trials for...[more]