Published Article

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication.

Tanner LB, Chng C, Guan XL, Lei Z, Rozen SG, Wenk MR. J Lipid Res. 2014 May 27;55(7):1357-1365.

Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is...


Published Article

Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

Wong LP, Lai JK, Saw WY, Ong RT, Cheng AY, Pillai NE, Liu X, Xu W, Chen P, Foo JN, Tan LW, Koo SH, Soong R, Wenk MR, Lim WY, Khor CC, Little P, Chia KS, Teo YY. PLoS Genet. 2014 May 15;10(5):e1004377. doi: 10.1371/journal.pgen.1004377. eCollection 2014 May.

South Asia possesses a significant amount of genetic diversity due to considerable intergroup differences in culture and language. There have been...


Published Article

The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MK, Shui G. Neurobiol Aging. 2014 Oct;35(10):2369-81

Despite its importance as the leading cause of vascular dementia, the primary pathogenic mechanisms in subcortical ischemic vascular dementia (SIVD)...


Published Article

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.

Curtis M. Schauder, Xudong Wu, Yasunori Saheki, Pradeep Narayanaswamy, Federico Torta, Markus R. Wenk, Pietro De Camilli & Karin M. Reinisch Nature (2014) doi:10.1038/nature13269

Growing evidence suggests that close appositions between the endoplasmic reticulum (ER) and other membranes, including appositions with the plasma...


Published Article

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Long N. Nguyen, Dongliang Ma, Guanghou Shui, Peiyan Wong, Amaury Cazenave-Gassiot, Xiaodong Zhang, Markus R. Wenk, Eyleen L. K. Goh & David L. Silver  Nature 509, 503–506 (22 May 2014)

Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance...